Amitriptyline

Amitriptyline

Amitriptyline is a sedative analgesic (painkiller) and antidepressant medication used to remedy chronic depression and various pain syndromes. This painkiller has been sold under the brand name Elavil and produced by an American pharmaceutical company by the name of Merck in the 1950s. Since then, Amitriptyline has been listed as a necessary drug for use by the World Health Organization (WHO) and has been used globally with prescriptions mounting annually. You can get this dual-acting medication delivered to you right here on our website.

Note: image for illustrative purposes only - FDA & EMA approved medication sold here.

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Pack of 28 x 50 mg tablets £32.99
Pack of 56 x 50 mg tablets £55.99
Pack of 84 x 50 mg tablets £78.99
Pack of 112 x 50 mg tablets £99.99
Pack of 140 x 50 mg tablets £119.99
Pack of 168 x 50 mg tablets £139.99

Amitriptyline has been tested countlessly and has also been approved by the Office of Generic Drugs Program for its high quality & efficacy. Our medications are very easy to acquire thanks to our no prescription policy and affordable prices that are five times cheaper than the original brand. Amitriptyline is effectively duel-acting and has additional beneficial treatment abilities.

Do you suffer from sporadic migraines? Are you struggling with severe depression? Or perhaps you just often encounter chronic back pain throughout the day? Regardless of your situation, read along further to discover what can be treated, how to take it, the benefits received, and many more.

What is Amitriptyline Used to Treat?

This analgesic aid is commonly used to treat and prevent classic migraines (Migraine Auras) from ruining a good day. Patients who suffer from neuropathic pain whether moderate to severe, often reported using Amitriptyline to alleviate their painful diabetic nerve damage. Nightly sleep disorders can be neutralized when this medication is taken in very low doses, reducing pain & fatigue so you get quality rest. Along with proper lifestyle changes, Amitriptyline has the potential to reduce the constant prevalence & length of chronic pain from post-surgery healing or severe injuries like a broken bone or a car accident.

Usually, if you experience symptoms like flickering bright dots, blind spots, or flashing lights, then these are warning signs of an arising migraine aura. Although Amitriptyline remedies peripheral neuropathy and fibromyalgia, it is a second-line use for managing the pain in non-chemotherapy patients when other opioids prove ineffective.

As this medication comes with minimal risk of dependency it is permissible for long-term use in persons who suffer from insomnia. People can use Amitriptyline for generalized anxiety disorder (GAD) or social anxiety with no risk of tolerance or addiction. Other indications show with selective use this analgesic solution can be effective for irritable bowel syndrome, cyclic vomiting, and bladder pain.

Amitriptyline Mechanism of Action

The exact mechanism of action has yet to be fully understood but we do know that Amitriptyline has a chemical tricyclic structure and other strengthening properties. This treatment medication stops the reabsorption of both serotonin and noradrenalin chemicals allowing concentration to build. This heightened potency is due to the synapses, a microscopic structure inside the central nervous system (CNS), it permits information signals in the form of nerve cells (neurons) to be passed. Potentially, the rate of caused action or pain can be targeted and controlled to reduce benign negative effects in your body.

Whereas one part of this drug can relieve pain and take it away, the counter-active property is its ability to offer a feeling of relief or goodness. Amitriptyline pills are binding agonists for serotonin receptors to modulate mood and increased data transferal within the CNS. By stopping the high voltage neuron firing pain reaction with gamma amino-butyric acid (GABA) agonist action, Amitriptyline releases its anti-anxiety & analgesic properties. This painkiller & 2nd option anti-depressant has many strengthening attributes, with the main location for strong anticholinergic action in both the central and peripheral nervous systems.

Amitriptyline Duration of Action

Though absorption of Amitriptyline is gradual, it is absorbed rather easily by the gastrointestinal tract to a percentage of 90 to 95%. After about 4 hours, the peak concentration of treatment will set in with a bioavailability percentage ranging from 30 to over 60%, due to some of the medication being pre-metabolized. Although the majority of its medicinal contents is received, much of it will be lost due to the first-pass metabolism expelling the effects before ever reaching the brain. Peak plasma concentration will ensue anywhere from two to twelve hours depending on the patients personal bio-mechanisms.

Amitriptyline has an average half-life of 21 to 25 hours. This time frame is how long it will take for half of the mg usage to be eliminated from your system. Thankfully with such a long half-life, there will never be a need to compound dosages or re-dose within a whole 24-hour day. Due to a longer duration of action, Amitriptyline can effectively be a continuous painkiller, treat sleep deprivation, and reduce intense anxiety. Due to the very low absorption of blood plasma, it may take longer than 2 weeks to feel desired benefits. Do be advised that this medication has a potential treatment latency of up to 4 to 6 weeks.

Dosage Instructions for Amitriptyline

Depending on your type of severe pain or anxiety, will greatly affect how much your dosage will reflect for usage. Amitriptyline is not an immediate migraine treatment but when taken at higher dosages, it can potentially help you avoid future migraines. The common starting dose no matter the infliction will usually start at 10 mg. Over time and tolerance gradually you can increase dosage as needed or prescribed up to but not exceeding the maximum dosage intake of 75mg. The three popular dose ranges used in both liquid and tablet form are 10mg, 25mg, & 50mg.

For sleep deprivation, we advise taking Amitriptyline an hour before bed due to its drowsiness effects. For oral reception, you will want to take 1 tablet by mouth with a full glass of room temperature water and swallow it simultaneously. We advise not to take this medication with any other prescription medications, illegal, or recreational drugs to avoid inconclusive results. To keep these tablets in the best quality condition, we advise to not place contents in a room with a temperature exceeding 25 degrees Celsius. Lastly, be aware not to chew, crush, or take Amitriptyline with heavy amounts of alcohol.

Does Amitriptyline Have Side Effects?

All manufactured supplements will have side effects whether mild or severe, Amitriptyline is very safe and has been FDA approved for use. Many patients of this treatment medication have reported no real side effects and if any, they were minor, tolerable, and went away on their own. This is why it is essential to always start with the lower dosages for any first-time treatment takers. However, listed are side effects to arise if encountered while on medication, and those are not limited to the following:

  • Urination difficulty
  • Drowsiness
  • Dry Mouth
  • Dizziness
  • Headache
  • Constipation

The best way to avoid the potential risk of Amitriptyline side effects would be to first update yourself on your current health conditions. The second would be to view previous reviews from experienced customers who grade products and correlate their interactions into a probable likeliness or unlikeliness of cause. If patients do experience any of these severe side effects when taking this medication, they should seek medical attention immediately. For more information and a full list of side effects associated with this medication, patients are advised to read the patient information leaflet available on our website.

Can Amitriptyline Be Used Long Term?

Amitriptyline is safe for long-term use. Studies reveal no lasting effects even if it is taken over an extended period of time. Remember that it is a low-dosage medication and the effects of relief will take some time depending on the genetics of the patient. Any benign nerve pain that takes longer than 28 days, may be best treated with an alternative medication and patients are advised to speak with a medical professional. There are no definitions for a true length of time for one particular medication, if you see the desired results, make a relative decision.

Leaving chronic pain untreated can be much more damaging over time, resulting in impaired immunity, sleep disturbances, and decreased mobility. On average, a pinched nerve can potentially last for up to six months. This means that is not unusual to take medication over an extended period of time. Knowing the extent of time needed to remedy pain will be based on a few signs to clarify the severity. Serious signs of nerve pain damage can suddenly arise as a sharp pain in your arms or legs, muscle weakness, or even numbness.

Should Anyone Avoid Amitriptyline

Patients who are already taking or thinking of consuming other medications will need to heed against serious side effects. Amitriptyline can be potentially hazardous to those individuals who take the following but are not limited to these medications:

  • Disulfiram
  • Arbutamine
  • Thyroid supplements
  • Ibuprofen/blood thinners
  • Anticholinergic drugs
  • Clonidine

We advise patients taking MAO inhibitors should avoid Amitriptyline altogether for potential serious risks. Also, women who are breastfeeding, pregnant, or trying to get pregnant, should avoid this medication as well. In addition to potential Amitriptyline reactions, certain physical conditions would constitute a reason for avoidance. If any of the following circumstances apply to you, please seek a medical opinion before moving forward with treatment. They are as follows:

  • If you ever had an allergic reaction to Amitriptyline
  • If you have liver or kidney problems
  • If you have glaucoma
  • If you have Type 1 or 2 diabetes
  • If you have a rare blood disorder called porphyria

Should you have any doubts, please speak to a medical professional before taking this or any other medication. Most importantly, if you are not aged 18 or over, you should not take this medication without professional or parental guidance.

Considerations Before You Buy Amitriptyline

When it comes to purchasing your Amitriptyline medications from either online sources or the high street, a few considerations need to be taken. Non-prescription medication (over the counter) can prove to be ineffective, has limited dosages, and are generally more expensive. Prices will change due to the local competition, hours are operationally designed, and typical on-site pharmacies have major employee overheads. Discounts are rare, great customer service will always be a gamble, and getting anything delivered will cost more of your patience than time.

When you purchase Amitriptyline here online you can receive a plethora of benefits to encourage your return. First is pricing, not only are our generic brands affordable, they are 5 times cheaper than original branded medications. In addition to that, when you bulk order your 3 to 6-month treatment, we will insert additional discounts from the savings we receive from being online.

We have 24/7 accessibility to our pharmacy, so you can shop at your timely discretion. Our shipping process is both secure and hassle-free. Your envelope will have no item names or descriptions on the surface to keep your privacy guarded. Enjoy our online purchasing process with easy to follow step-by-step instructions. All the help you need is provided and our customer service team is on standby 24/7 to assist further if required.

Where to Buy Amitriptyline in the UK

Now that we have answered and outlined the many details about Amitriptyline, the first step you must take to rid your life of pain is to place your order. When you enter our pharmacy, which offers one of the biggest selections of analgesic medications available in the UK, you can browse the potential solutions that we have available. Select the desired treatments and the respective amounts, remembering that you save more when you order larger quantities. You will be requested to make an online secure payment, which can be done using Bitcoin, MasterCard, Visa, or bank transfer (If in the UK).

Upon payment completion, you will immediately be sent an email with your delivery date details, as well as the anonymous descriptor name that will appear on your bank statement. Orders being delivered inside of the UK can be expected to arrive in 2-4 business days, while UK-EU orders will take an average of 4 - 7 days. If any problems arise during any part of this process, please reach out to our customer service team who are available 24-hours a day.

Order Amitriptyline right here at Sleeping Tablets Direct and take the first step to a new and happier you. Do it today and start living again.

Last Reviewed: 28/06/22

Important Information

While this medication may be consumed with or without food, it is not recommended that patients consume it on a completely empty stomach. Likewise, the effects of this medication will be dulled, or seem weaker, if taken on a full stomach, or after eating a heavy meal.

This Medication Should:

  • be consumed in accordance with the patient information leaflet.
  • be swallowed whole; do not crush, chew or suck these tablets / capsules.
  • be stored in a cool dry place / at room temperature (20°C - 25°C).
  • be kept out of the reach of children at all times (minors under the age of 18).

This Medication Should Not

  • be mixed with alcohol - even one drink can be dangerous.
  • be used if pregnant, breastfeeding (or planning to become pregnant).
  • be shared - even with friends or family experiencing symptoms similar to yours.
  • be taken when planning to drive or operate dangerous machinery.

NOTE: If you, or anyone you know, have taken too much of this medication, or if you are experiencing any unwanted side-effects such as a rash, difficulty breathing or swelling of any kind, you should contact a doctor immediately.

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Customer Reviews from TrustPilot

  • Trustpilot Reviews
    Jun 15, 2021 – Nerile N

    I have ordered my meds on Friday…

    I have ordered my meds on Friday received it today( Tuesday) was perfect. Ordered 28 tablets but got 30 😊👏🏻👏🏻 Haven't taken one yet but opened the capsule and tasted the powder inside and because I have been taking pregablin for ages it definitely taste like the real deal. Will try it properly tomorrow. But so far so good and I'm very impressed! Thank you.

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    May 28, 2021 – Watson

    EXCELLENT

    I have used this site for a quite some time now. It is quick easy and straight forward to navigate. I have been completely satisfied with the service. Products come exactly as described and well packed. Professional service.

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    May 28, 2021 – Arnold

    Happy Customer!

    Recommended by my friends about this website. I'm a happy customer legit product and company.
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Note: These comments may be edited / shortened to fit the allocated space

More Customer Reviews

Loraine Carolan – Feb 07, 2022
I would like a few amitriptyline to help the pain in my back some time I can always sleep with it.
Graham Jones – Aug 16, 2021
An excellent addition to your website. Great to finally get this medication online. Graham Jones
Kirsten Smith – Jul 30, 2021
I cannot recommend this medication highly enough. I have been living with pain for some time and this medication provides the relief I need. Kirsten Smith

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